Associations between training characteristics and change in peak oxygen consumption following exercise training in patients with heart failure with preserved ejection fraction

Abstract Introduction In heart failure with preserved ejection fraction (HFpEF), moderate continuous training (MCT) and high-intensity interval (HIIT) are both effective in increasing peak oxygen uptake (peak V̇O2). Purpose The aim of this study was to investigate the association characteristics (i.e. average sessions/week, duration/week, mean intensity) change V̇O2 following 3 months MCT HIIT patients HFpEF. Methods Among 120 who were randomized (5x40 min/week at 35–50% rate reserve [HRR]) or (3x38 80–90% HRR), those completed 3-month follow-up (N=107) considered for analysis. Training duration rates [HR] recorded a smartphone application, evaluated customized software manually checked plausibility. If HR measurements classified as invalid/unreliable (e.g. very strong fluctuations), excluded from Intensities calculated % HRR total sessions highest values all intervals HIIT. Associations between using univariate multivariate regression analyses. Individual HR-V̇O2 relationships used calculate compare energy expenditure (MET-minutes) Results After excluding 16 due data, 91 (67% female, 69±7 years) included On average, (N=45) performed 4.0±1.2 sessions/week (162±52 min/week) 47.4±6.7% HRR, while (N=46) 2.4±0.8 (96±40 81.8±11.8% HRR. Peak improved by 1.70±2.35 ml/kg/min 1.46±2.98 (difference: 0.24 [95% CI, −0.87 1.34], p=0.67). associations shown Fig.1. Mean not significantly associated group, whereas MCT, duration/week intensity similar relative importance (standardized coefficients) explained up 26% variation (Table 1). Average weekly MET-minutes above rest 451±260 389±375 62 −71 195], p=0.36). adjustment MET-minutes, difference groups diminished 0.09 (95% −0.97 1.16; p=0.98). Conclusions Weekly had predictive ability with, interestingly, lower intensity. HIIT, V̇O2. adjusting expenditure, modes diminished, suggesting that similarly effective. Funding Acknowledgement Type funding sources: Public grant(s) – EU funding. Main source(s): European Commission, Framework Program 7